RM SITAGLIPTIN 50MG TAB

Medicine Information

What is this medicine used for?

For non-insulin-dependent diabetes (type 2) in adults, when dietary measures and exercise alone are not sufficient to control blood glucose.

How much and how often should you use this medicine?

DOSAGE AND ADMINISTRATION

• As an adjunct to diet and exercise to improve glycemic control: Monotherapy or in combination with other antidiabetic agents: 100 mg once daily. May be taken with or without food.
• Renal Impairment: ESRD requiring haemodialysis or peritoneal dialysis: 25 mg once daily; may be given without regard to the timing of dialysis. eGFR <30 mL/min/1.73 m2: 25 mg once daily. eGFR ≥30 to <45 mL/min/1.73 m2: 50 mg once daily.

Contraindications

Contraindications to gliptins include type 1 diabetes and diabetic ketoacidosis. Sitagliptin is contraindicated in individuals who are sensitive to the drug or its components. Caution is necessary when using gliptins in patients with a history of pancreatitis; it would be reasonable to discontinue these drugs if pancreatitis is suspected.

Dose adjustments are necessary for patients with renal insufficiency taking sitagliptin and saxagliptin as these drugs undergo renal excretion; failure to adjust the dose could increase the chance of hypoglycemia.

Warning and Precautions

Precautions:

• This treatment should be prescribed only if the patient is likely to have a regular food intake (including breakfast). It is important to have a regular carbohydrate intake due to the increased risk of hypoglycemia if a meal is taken late, if an inadequate amount of food is consumed, or if the food is low in carbohydrate.
• Hypoglycemia is more likely to occur during low caloric diets, following prolonged or strenuous exercise, alcohol intake, or if a combination of hypoglycemic agents is being used.
• Because of the possibility that Sitagliptin may have a harmful effect on the fetus, it should not be used during pregnancy.
• Hypoglycemia may occur following administration of Sitagliptin. Some cases may be severe and prolonged. Hospitalization may be necessary and glucose administration may need to be continued for several days. Careful selection of patients, of the dose used, and clear patient directions are necessary to reduce the risk of hypoglycemic episodes.

Availability

• RM Sitagliptin 50 mg box of 30s

Indication

For non-insulin-dependent diabetes (type 2) in adults, when dietary measures and exercise alone are not sufficient to control blood glucose.

Ingredients

Each tablet contains: RM Sitagliptin 50mg